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Int J Neuropsychopharmacol 27(2):pyae009 Liu C-Y, Huang C-J, Huang L-H, Chen I-J, Chiu J-P, Hsu C-H (2014) Effects of green tea extract on insulin resistance and glucagon-like peptide 1 in patients with type 2 diabetes and lipid abnormalities: a randomized, double-blinded, and placebo-controlled trial

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Subsequently, a relevant novel autoregulation function for IGF-1R was reported [3] revealing that IGF-1R not only translocates to the nucleus but also specifically binds to its own promoter in ER BrCa cells

For a patient, that combination reads as a genuine trade-off rather than a clean win